MicroRNAs (miRNAs) are generated from local hairpin structures by the action of two RNase III-type proteins, Drosha and Dicer. Mature ∼22-nucleotide (nt) miRNAs are then bound by Ago-subfamily ...

Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA, cleaves at a single-stranded region in the mRNA 3'UTR.