In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... elucidating the unique biochemical requirement for a 2’-PO 4 in the ligation step of ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

1 Alternative splicing will sometimes introduce a premature stop codon into an mRNA, which NMD will recognize as an mRNA that needs to be degraded. “It's a very common mechanism of downregulation,” ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

"By targeting key processes like RNA splicing and modification ... Leslie's powerful and robust model systems to nail down this novel mechanism," said co-corresponding author Robert Spitale ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

Role of RNA Splicing in Gynecological Pathologies We recently reported an increase in the ... we are interested in evaluating the underlying molecular mechanism of the functions of autophagy related ...

SEED Therapeutics announced that the U.S. Food and Drug Administration has granted Rare Pediatric Disease and Orphan Drug designations to ...