MHC denotes major-histocompatibility complex, ... Lu SX, De Neef E, Thomas JD, et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 2021;184(15):4032-4047.e31. Crossref.

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

Spliceosomes are large and dynamic RNA-protein complexes. The major spliceosome consists of five subunits, U1, U2, U4, U6, and U5 small nuclear ribonucleoprotein particles (snRNPs, read "snurps ...

Splicing kinetics for the pre-formed native complex and for reactions of free RNA were fit to a first order exponential, f first order = Ae −kt + (1 − A), where f is the fraction unspliced RNA ...

RNA splicing is the process by which the initial RNA copy of a gene, ... This capacity is believed to be critical to the complex workings of human cells such as those found in the neurons of the ...

RNA splicing ribozymes have been shown to possess a conserved active site ... a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the ...

To carry out RNA splicing, cells use the spliceosomal complex, a multiprotein cellular machinery that coordinates the production of mature RNA molecules. RNA splicing is one of the important ways by ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...

While DNA is largely fixed, RNA-splicing involves a complex and murky mix of variables. And that’s where AI comes in, explained Martin Akerman, Envisagenics’ co-founder and chief technology ...

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

RNA splicing, a process discovered ... "Complex splicing machinery" Previous work has shown that mutation or deletion of one of the LUC7 proteins that bind to right-handed splice sites is linked ...