However, this approach does not address transcriptome complexity in alternative splicing and transcription ... The next big challenge for RNA-Seq is to target more complex transcriptomes to ...

RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

Biologists have discovered that disruptions in transfer RNA function can lead to the development of cleft lip and cleft palate.

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... We recently solved a 2.2 Å crystal structure of the Candida Trl1 kinase domain in complex with ...

The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than ...

Spliceosomes are large and dynamic RNA-protein complexes ... step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Ultimately, the spliced messenger RNA consists of only protein-encoding ... It is absolutely vital that the splicing complex accurately recognizes exon-intron-exon junctions so the needed cuts ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...

The research work forms the potential basis for more complex RNA machinery. One major challenge in constructing synthetic cells is manufacturing proteins, which are responsible for nearly all ...