Splicing kinetics for the pre-formed native complex and for reactions of free RNA were fit to a first order exponential, f first order = Ae −kt + (1 − A), where f is the fraction unspliced RNA ...

The production of different proteins from a single gene results from the interplay between RNA-binding proteins (RBPs) and splice sites located throughout the pre-mRNA transcript. 5 The primary RBP ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

MHC denotes major-histocompatibility complex, ... Lu SX, De Neef E, Thomas JD, et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 2021;184(15):4032-4047.e31. Crossref.

RNA splicing, a process discovered ... "Complex splicing machinery" Previous work has shown that mutation or deletion of one of the LUC7 proteins that bind to right-handed splice sites is linked ...

RNA splicing ribozymes have been shown to possess a conserved active site ... a complex process by which the information contained in DNA is copied into RNA to eventually give rise to all the ...

RNA splicing is the process by which the initial RNA copy of a gene, ... This capacity is believed to be critical to the complex workings of human cells such as those found in the neurons of the ...

To summarize, the study identified RNA splicing errors as a major source of tumor-specific neoantigens in gliomas, offering ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...

While DNA is largely fixed, RNA-splicing involves a complex and murky mix of variables. And that’s where AI comes in, explained Martin Akerman, Envisagenics’ co-founder and chief technology ...