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A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
微小 RNA(miRNAs)大多通过影响 DNA-PKcs 来影响化疗或放疗中的 DNA 损伤修复(DDR),如 miR-488-3p 可调节恶性黑色素瘤细胞对顺铂的敏感性 3 4 。 DNA-PKcs 在可变剪接中的作用 :可变剪接(AS)是产生转录组多样性的重要机制,DNA-PKcs 参与前体 mRNA 的可变剪接。
The Catalyst: RNA and the Quest to Unlock Life’s Deepest Secrets. Thomas Cech. W.W. Norton; 304 pages; $28.99 and £23.99 W hat you see depends on how you look. For years students of cell bio ...
为明确 Ku-RNA 相互作用在野生型细胞中的生理作用及 Ku 在人类细胞中必要性,研究发现 Ku 缺失通过 dsRNA 传感器 MDA5/RIG-I 和 MAVS 诱导 IFN 及 NF-κB 信号,其与灵长类 Alu 元件扩增密切相关,揭示 Ku 对灵长类适应 Alu 扩增的重要性。
研究团队利用云计算与ai技术发现超16万种新rna病毒,是已知种类的近30倍,深化了对rna病毒多样性和演化历史的认知,并带来病毒学新发现。
本研究基于天然存在的 R2 逆转录转座子,开发出了一种全 RNA 介导、高效、精确的基因写入技术。 在一项新的研究中,中国科学院动物研究所研究员 ...
And RNA is a crucial element of the modern suite of gene-editing techniques that began with CRISPR-Cas9. Not a bad record, then, for what was once molecular biology’s also-ran.
The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...
RNA editing of genomic neighbors controls antiviral response in fungi. Cell Host & Microbe , 2025; 33 (4): 545 DOI: 10.1016/j.chom.2025.02.016 Cite This Page : ...
Scientists develop RNA-based technology to combat plant viruses, enhancing crop immunity and reducing losses worldwide. In India, CMV is responsible for 25-30% yield losses in banana plantations.
Through international collaboration, researchers at KAIST have revealed that RNA editing plays a crucial role in regulating neuroinflammation, a key pathology of Parkinson's disease.