Riboglow, a collaboration between the Palmer and Batey labs in the Department of Biochemistry at CU Boulder, is a new take on these RNA-imaging tools based on naturally occurring RNA sequences, called ...

Biomolecular condensates are shifting blobs in our cells that organize cellular matter. They are distinct molecular ...

在生命科学领域，基因编辑技术的每一次革新都深刻影响着疾病治疗的未来。近年来，随着基因编辑技术的迅速发展，RNA编辑作为一种新兴的治疗方法，受到了科学界和产业界的广泛关注。与传统的DNA编辑相比，RNA编辑避免了对遗传信息的永久改变，具有可逆性和可控性，极大地提高了基因编辑技术的安全性。但现有的RNA编辑技术大多集中在单碱基编辑领域，极大了限制了RNA编辑的临床应用场景。

2025年2月18日，诺贝尔化学奖得主、CRISPR 基因编辑技术先驱 Jennifer Doudna 教授团队在 Nature Biotechnology 期刊发表了题为：Single-molecule live-cell RNA imaging ...

Spatial transcriptomics is a cutting-edge technique that characterizes gene expression within sections of tissue, such as ...

Genes have to be expressed in the right place, at the time, and at the right levels. Scientists wanted to know more about how ...

Researchers use high-resolution imaging to reveal the dynamic structure of biomolecular condensates, shedding light on their ...

For the Liu Lab, necessity is truly the mother of invention. The researchers were examining how the 3D organization of the ...

Robert Singer and colleagues at the Albert Einstein College of Medicine had been using the MS2 coat protein fused to fluorescent proteins to label RNA for imaging in living cells. “But the ...

Janelia researchers developed an innovative new technique – cycleHCR -- that uses a novel DNA barcode system to track hundreds of RNA and protein molecules in single cells within thick biological ...

The flexibility of RNA makes it notoriously challenging to study, as its structure can shift into numerous forms depending on environmental conditions. Traditional imaging methods, such as cryo ...