RNA abundance is regulated by balancing transcription and degradation in processes that control the temporal and spatial distribution of cellular RNA. In eukaryotic cells, mRNA decay is catalyzed by ...

编辑推荐：为解决真核生物中RNA外切体(exosome)靶向降解的分子机制问题，研究人员发现内含子多聚腺苷酸化(intronic polyadenylation)产生的RNA通过5'剪接位点(5' ss)与多聚腺苷酸连接位点(PAJ)组合形成"核RNA降解密码"(NRDC)，被U1 snRNP和CPA因子协同招募的PAXT-外切体复合体 ...

Samples are commonly stored in a way that degrades RNA. Scientists are devising new ways to overcome this obstacle for RNA sequencing. RNA is more subject to degradation than DNA, whether chemical, ...

A universal feature of stable RNAs is that they are transcribed as 3′ extended precursor molecules that undergo subsequent processing events, generally exonuclease digestion, to generate the 3 ...

Studies have shown that the copy numbers of individual mRNA species in whole blood can change more than 1000-fold during storage or transport at room temperature, due to rapid RNA degradation and ...

Unlike animals, plants do not possess an adaptive immune system with antibodies or T cells to fight viral infections. Instead, they rely on the RNA silencing system, which serves as their innate ...

siRNAs mediate mRNA cleavage and degradation, leading to potent and specific gene silencing. miRNAs are endogenous, single-stranded RNA molecules of about 22 nucleotides that regulate gene expression ...

These RNA molecules can interact with mRNA, influencing its stability, translation, or degradation, thus fine-tuning protein production in the cell. RNA interference (RNAi) is a cellular mechanism ...

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise ...

Are you looking to solve challenges with current RNA therapeutics, such as the degradation of RNA by RNAses, the difficulty of RNA crossing the cell membrane by diffusion and the immunogenicity ...