A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a protein that regulates ribonucleic acid (RNA) induced immune responses. Their ...

Researchers have identified cellular factors that regulate the delivery and stability of mRNA to expand the potential of mRNA ...

Enter the anti-CRISPR protein AcrVIB1 ... The simpler and therefore initially expected mechanism would have been to just prevent the guide RNA from binding in the first place," says first author ...

unfolded protein response). RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO 4 and 5’-OH ends; or (ii) via a hydrolytic mechanism that leaves 3’-OH and ...

A team of researchers led by Dr. Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science ...

A team of researchers led by Dr. KIM V. Narry, director of the Center for RNA Research at the Institute for Basic Science ...

Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.

ADAR1's RNA editing mechanism Researchers used ... underscores the essential role of RNA-binding domain 3, a key portion of ADAR1, in maintaining the protein's activity and stability.