unfolded protein response). RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO 4 and 5’-OH ends; or (ii) via a hydrolytic mechanism that leaves 3’-OH and ...

Finally, it is not at all clear why a substrate binding pocket ... Nevertheless, the mechanism by which the three domains of the protein and domain IV of SRP RNA work in concert to recognize ...

A research team led by Rice University’s Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

A research team led by Rice University's Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a ...

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...

Enter the anti-CRISPR protein AcrVIB1 ... The simpler and therefore initially expected mechanism would have been to just prevent the guide RNA from binding in the first place," says first author ...

Researchers uncover new insights into the molecular mechanisms of ADAR1, a protein that regulates RNA-induced immune responses. Their findings could open new pathways for treating autoimmune diseases ...

These rRNAs are involved in mRNA binding and decoding. Large Subunit rRNAs ... which catalyzes the formation of peptide bonds between amino acids during protein synthesis. This discovery led to the ...

But in cancer, this safety mechanism often fails ... grow-suggesting that targeting the RNA rather than the protein could be a more effective approach. "This tells us that poison-exon-containing RNA ...

Breakthrough discovery in cancer research! Scientists uncover a simple genetic strategy to combat aggressive cancers. Learn ...

A study reveals how cancer disrupts RNA splicing and presents a potential therapy using antisense oligonucleotides to target ...