During transcription, RNA polymerase (RNAP) moves processively along a DNA template, creating a complementary RNA. Here we present the development of an ultra-stable optical trapping system with ...

The most common type of base pairing is the Watson-Crick base pair, named after James Watson and Francis Crick, who first proposed the double helix structure of DNA. In this type of pairing, adenine ...

Figure 1: RNA polymerase transcription and proofreading studied by optical trapping. We studied transcription by RNAP at physiological nucleotide concentrations using a new single-molecule assay ...

RNA Therapeutics: From Base Pairs to Bedsides Symposium 28 June 2018 08:00 - 29 June 2018 18:00, Worcester, United States ... Throughout the latter half of the 20th century, we believed that RNA’s ...

Uracil is a key nucleobase in RNA, forming base pairs with adenine. It plays crucial roles in RNA structure, function, and the genetic code, with ... Both uracil and thymine pair with adenine, but ...

This base editor can essentially reverse or rewrite specific base pair mutations. "CRISPR is like scissors, and base editors are like pencils," says David Liu of this new innovation.

RNA Therapeutics: From Base Pairs to Bedsides Symposium 28 June 2018 08:00 - 29 June 2018 18:00, Worcester, United States ... Throughout the latter half of the 20th century, we believed that RNA’s ...

Base editors were first developed in 2016 and 2017 at the laboratory led by David Liu, PhD, at Harvard University. They directly convert one DNA base pair at a specified position in the genome of ...

RNA forms in the nucleolus, and then moves to specialized regions of the cytoplasm depending on the type of RNA formed. Reactivity: Due to its deoxyribose sugar, which contains one less ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts.