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ING5 inhibits aerobic glycolysis of lung cancer cells: Study
The results revealed that ING5 overexpression significantly increased PDK1 phosphorylation at Y163, which in turn negatively regulated PDK1 kinase activity towards pyruvate dehydrogenase E1 ...
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Saol Therapeutics announces FDA acceptance of New Drug Application for SL1009 for treatment of Pyruvate Dehydrogenase Complex Deficiency
DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.
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ING5 regulates metabolic reprogramming in lung cancer cells
The results revealed that ING5 overexpression significantly increased PDK1 phosphorylation at Y163, which in turn negatively regulated PDK1 kinase activity towards pyruvate dehydrogenase E1 ...