Traditional methods for determining binding sites and affinities typically require the purification of recombinant proteins, which can be both time-consuming and labor-intensive. In addition ...

Isomorphic Labs, a spin-off from DeepMind, is applying AI-first principles to drug discovery rather than just protein ...

This occurs because multiple copies of the regulatory protein binding sites exist within the genome of a cell. Consequently, regulatory proteins can have different roles for different genes ...

then lead to the clumping of the protein and subsequent disease. Attaching the ATTR drug tafamidis—developed by the Kelly lab—to one or both of the transthyretin binding sites, they then found, ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

Biological scientists from the National University of Singapore (NUS) have uncovered how the dengue virus uses its envelope ...

"A key feature of our method is blind docking, which predicts how the redesigned protein interacts with its ligand without the need for predefined binding site information," Hy said. "This ...

Proteins interact with DNA to regulate many vital processes in cells. Nearly 40 years ago, researchers developed a way to map these molecular connections. Mariella is an assistant editor at The ...

Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.

“A key feature of our method is blind docking, which predicts how the redesigned protein interacts with its ligand without the need for predefined binding site information,” Hy said. “This streamlined ...