Traditional methods for determining binding sites and affinities typically require the purification of recombinant proteins, which can be both time-consuming and labor-intensive. In addition ...

This asymmetry in the native structure of transthyretin also presents a hypothesis for how the process of dissociation and ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

Lis and Gilmour focused on identifying proteins that bound to specific chromatin sites to understand the mechanisms of gene regulation. To do so, they planned to stabilize proteins at their chromatin ...

"A key feature of our method is blind docking, which predicts how the redesigned protein interacts with its ligand without the need for predefined binding site information," Hy said. "This ...

“A key feature of our method is blind docking, which predicts how the redesigned protein interacts with its ligand without the need for predefined binding site information,” Hy said. “This streamlined ...

Please provide your email address to receive an email when new articles are posted on . Presence of a protein-binding biomarker in a small cohort of adults with depression may be an indicator that ...

Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.