The poly-A tail is a long chain of adenine nucleotides that is added to a messenger RNA (mRNA) molecule during RNA processing to increase the stability of the molecule. Immediately after a gene in ...

tail length and promote translation of maternal mRNA"的研究工作。该研究揭示了一种早期胚胎母源mRNA poly(A)尾保护机制。 研究团队在前期对比小鼠的类2细胞胚胎 ...

Get Instant Summarized Text (Gist) A mechanism regulating mRNA poly(A) tail length in early embryos has been identified, involving the protein MARTRE1, which inhibits the CCR4-NOT complex. MARTRE1 ...

Regulation of the poly(A) tail is essential for selective protein translation in early embryos. However, the mechanisms that determine and maintain the length of maternal mRNA poly(A) tails remain ...

An evolutionarily conserved mRNA-degradation pathway is initiated by the removal of the 3′ poly(A) tail. This disrupts the translation initiation complex and provides degradative enzymes with ...