“Phospho-tau in blood is not as specific as everyone would like to ... produced in the brain from tau produced elsewhere in the body, based on portions of the protein that are spliced out in the brain ...

Get Instant Summarized Text (Gist) Glutamate, a neurotransmitter, can lead to a toxic buildup of tau protein, contributing to Alzheimer's and related diseases. Research using lab mice and human ...

However, the clumping of tau protein into well-ordered structures ... More information: Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's ...

Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

recognizes the PKA-dependent phosphorylation of ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...