这项研究中，研究人员开发了一种新型鼻腔喷雾（nasal spray），其能清除工程化改造拥有人类样阿尔兹海默病症状小鼠大脑中的tau蛋白。 在阿尔茨海 ...

The scientists produced these organoids from stem cells derived from healthy people as well as from patients with ...

However, the clumping of tau protein into well-ordered structures ... More information: Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's ...

Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

recognizes the PKA-dependent phosphorylation of ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts ...

Study: Phospho-tau serine-262 and serine-356 as ... Patients with advanced AD typically exhibit intracellular insoluble tau protein, forming neurofibrillary tangles (NFTs), alongside amyloid ...

A team of researchers from the University of Cologne has made an important contribution to understanding the role of the tau protein in Alzheimer's disease. A specific variant of the tau protein ...

A complementary drug to combat Alzheimer’s disease could target a specific part of the nerve cell protein tau. This is the finding of research from the University of Gothenburg, which also ...