Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

The amyloid cascade hypothesis that deposition of Aβ in the brain initiates Alzheimer's disease pathogenesis, "leading to subsequent tau deposition ... ApoE protein is a lipid-binding protein ...

The present work is undertaken to enhance our understanding of the pathogenesis of Alzheimer’s disease ... Finally, we test our hypothesis that unbalanced expression of tubulin and tau leads to ...

since the nuclear location of this protein should prevent it from triggering an inflammatory cascade. HMG1 nevertheless seems to have a role in the pathogenesis of arthritis, since its ...

Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

The neurotransmitter glutamate is essential for regulating everything from mood to memory, but it can also encourage a toxic buildup of the notorious tau protein, which can contribute to Alzheimer ...

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau. This discovery ...

When exposed to glutamate, the organoids—particularly the ones derived from patients with neurodegenerative ...

USC Stem Cell scientists discover a new way to rid cells of toxic tau protein in a study involving mice and lab-grown human “mini-brains,” known as organoids. The neurotransmitter glutamate is ...

How to clear the toxic tau protein that can lead to Alzheimer's and related diseases. ScienceDaily . Retrieved April 2, 2025 from www.sciencedaily.com / releases / 2025 / 03 / 250305134659.htm ...

Get Instant Summarized Text (Gist) Glutamate, a neurotransmitter, can lead to a toxic buildup of tau protein, contributing to Alzheimer's and related diseases. Research using lab mice and human ...