Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

However, research has also linked glutamate to the toxic accumulation of tau protein – a hallmark of neurodegenerative diseases like Alzheimer’s. A recent study led by scientists at USC Stem Cell, ...

The amyloid cascade hypothesis that deposition of Aβ in the brain initiates Alzheimer's disease pathogenesis, "leading to subsequent tau deposition ... ApoE protein is a lipid-binding protein ...

An oral small molecule from New York-based biotech Oligomerix curbed the tangling of tau protein in the brains of mice that model a rare neurological disease. The results, published on March 12 in ...

The present work is undertaken to enhance our understanding of the pathogenesis of Alzheimer’s disease ... Finally, we test our hypothesis that unbalanced expression of tubulin and tau leads to ...

A comprehensive toolkit for spatial biology Orr’s team follows protein expression across ... It's another step towards understanding tau pathogenesis and cellular senescence, and their links ...

To understand why certain parts of the brain are more affected by Alzheimer's disease, researchers focused on tau, a protein that accumulates in brain cells and disrupt normal activity.

As previously announced, results from the Phase 1b study showed dose-dependent reductions in soluble tau protein in cerebrospinal fluid (CSF), decreases in aggregated tau pathology in the brain as ...

Aβ accumulation and plaque formation are central to AD pathogenesis. CD2AP has been found to regulate Aβ metabolism by controlling the trafficking and degradation of amyloid precursor protein (APP).