A comprehensive toolkit for spatial biology Orr’s team follows protein expression across ... It's another step towards understanding tau pathogenesis and cellular senescence, and their links ...

Phosphorylation enables tau protein to undergo reversible liquid–liquid phase separation (LLPS), forming micrometer-sized droplets, a property not seen in unmodified tau.

But now, Canadian scientists say children who have Dad's with Alzheimer's are more prone to one toxic protein, tau, spreading in the brain. Significant clumps of this protein, as well as anothe ...

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. We were surprised to see that people with a father with Alzheimer's ...

The amyloid cascade hypothesis that deposition of Aβ in the brain initiates Alzheimer's disease pathogenesis, "leading to subsequent tau deposition ... ApoE protein is a lipid-binding protein ...

The study also showed that female participants may be more at risk of a heavier buildup of tau protein than male participants. "We were surprised to see that people with a father with Alzheimer's ...

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau. This discovery ...

The scans are also expensive and not available at all hospitals. More sensitive ways to detect amyloid and tau, another protein related to the disease, are possible by analyzing spinal fluid ...

They found that levels of a protein called MTBR-tau243 correlate to the amount of tau that has accumulated in the brain, according to a WashU press release. Accuracy compared to brain scans was 92%.

As previously announced, results from the Phase 1b study showed dose-dependent reductions in soluble tau protein in cerebrospinal fluid (CSF), decreases in aggregated tau pathology in the brain as ...