Tau is a protein that builds up and moves between nerve cells in the brains of people living with Alzheimer’s disease, causing damage. Professor Mudher is using clever genetic manipulation in fruit ...

Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

since the nuclear location of this protein should prevent it from triggering an inflammatory cascade. HMG1 nevertheless seems to have a role in the pathogenesis of arthritis, since its ...

When exposed to glutamate, the organoids—particularly the ones derived from patients with neurodegenerative ...

The amyloid cascade hypothesis that deposition of Aβ in the brain initiates Alzheimer's disease pathogenesis, "leading to subsequent tau deposition ... ApoE protein is a lipid-binding protein ...

Stem cell scientists from the University of Southern California (USC) and elsewhere have found a way to potentially clear out the buildup of tau protein in the brain, which is associated with the ...

A protein that impacts Alzheimer’s disease offers new opportunities for targeted treatments, although its cell-specific ...

A team of researchers from the University of Cologne has made an important contribution to understanding the role of the tau protein in Alzheimer's disease. A specific variant of the tau protein ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...

Tau is a protein that is found in cells of the central nervous system and is involved in the assembly and stabilisation of neuronal microtubules – channels used to transport substances to ...

A groundbreaking peer-reviewed Thought Leaders Invited Review article in Brain Medicine (Genomic Press, New York) explores how CD2-associated protein (CD2AP) contributes to Alzheimer's disease (AD), ...