The crystal structure of ... Structures of the receptors in their multiple active conformations, stabilized with ligands, should ultimately elucidate the molecular mechanisms of receptor activation.

However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein–coupled receptors (GPCRs ... made in understanding the molecular details of how Gα subunits ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...