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Scientists uncover rapid-acting, low-side-effect antidepressant target
The mechanistic (or mammalian) target of rapamycin (mTOR) signaling pathway, implicated in rapid antidepressant effects, was investigated for its role in KNT-127's action. The researchers injected ...
Nature4d
Targeting the phosphoinositide 3-kinase pathway in cancer
Inhibitors that target key components of this pathway, including PI3K, AKT and mammalian target of rapamycin (mTOR), are being actively developed. Some of them have reached clinical trials in ...
Nature6y
Rapamycin hits the target
Charles Sawyers and colleagues have conducted a small early-stage clinical study to assess target modulation by the small-molecule inhibitor rapamycin. Rapamycin is approved to treat renal cancer ...
Hosted on MSN1mon
New insights into mTOR pathway offer hope for diabetic nephropathy treatment
A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its ...