Inability of cells to recycle fats can spell disease: Study reveals how a protein helps transport fats out of lysosomes
Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...
The Scientist2y
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Damaged lysosomes are repaired by a lipid-based signaling pathway ... who was not involved in the study. But the pathway might function differently in other cells, including neurons, so more work is ...
Nature12y
The Discovery of Lysosomes and Autophagy
The discovery of lysosomes led to many new questions. The most critical question was: what was the physiological function of this "bag" of enzymes? The Function of Lysosomes One of the definitive ...
Hosted on MSN1mon
Chemists discover a key protein in how lysosomes work
The function of lysosomes is tightly regulated by complex cellular signals, including calcium ions moving into and out of lysosomes. Scientists have known how lysosomes release their calcium since ...
technologynetworks10d
How Cells Recycle Important Fat Molecules To Stay Healthy
New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat ...
Nature8d
Lysosomes articles from across Nature Portfolio
During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Although effector activity and memory formation in CD8 ...
Medindia9d
How Cellular Mechanisms Recycle Fat and Protect Against Rare Diseases
The protein Spns1 helps transport fat molecules out of lysosomes, preventing harmful buildup and offering insights for rare ...
Baylor College of Medicine2y
TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy
Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...