1). In the 'off' state, the Lac inhibitor represses the lac operon, which prevents expression of the Tet repressor and the target gene. Additionally, a short hairpin RNA (shRNA) against the target ...

Mutations that disrupt the trpR gene lead to elevated production ... For example, repression of the lac operon by its repressor, called lacI, is inhibited by the ligand allolactose, to which ...