Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

Scientists from the University of Cologne identified the 1N4R tau isoform as a key contributor to neuronal dysfunction in ...

A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein ...

Scientists have identified the 1N4R tau isoform as a key driver of Alzheimer’s disease, paving the way for potential new ...

The neurotransmitter glutamate is essential for regulating everything from mood to memory, but it can also encourage a toxic ...

A team of researchers from the University of Cologne has made an important discovery about Alzheimer’s disease. They found ...

Antibodies specific to tau’s mid-section or MTBR/R’ regions stymied anti-synaptic activity of these preparations. Strikingly, the injected human tau lingered in the rat hippocampus for three weeks ...

The hunt for blood-based biomarkers is continuing apace. At the Human Amyloid Imaging (HAI) meeting, held January 15-17, researchers focused on new techniques—all based on tau and blood, conference ...