This two-pronged assault on the mitochondrial apoptotic machinery identifies HSP90 inhibitors as promising drugs for targeting the TYK2-mediated prosurvival signaling axis in T-ALL cells.

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the dysregulation ... This work has enhanced our understanding of the oncogenic ...

Hsp90 has an important role in regulating diverse oncogenic signaling mechanisms by stabilizing and folding key proteins involved in carcinogenesis and is a highly sought after target for cancer ...