Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Elliott B, Richardson C, Winderbaum J, Nickoloff JA, Jasin M. 1998 Gene conversion tracts from double-strand break repair in mammalian cells in mammalian cells. Mol Cell Biol. 1998;18:93-101. Johnson ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Different genomic alterations in DNA damage repair (DDR) pathways occur in 20% to 25% of advanced prostate cancer, including homologous recombination repair (HRR) gene alterations. Identifying the ...

Combining BET inhibitors and PARP inhibitors might help patients resistant to chemotherapy, the study suggests.