The article by Bergstrom et al entitled “Deep Learning Artificial Intelligence Predicts Homologous Recombination Deficiency and Platinum Response From Histologic Slides” (Journal of Clinical Oncology ...

Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, ...

We already showed that AsiDNA disrupts the homologous recombination repair in different HRP tumor models, and therefore, induces a functional HRD that sensitizes HRP tumors to PARP inhibitors.

Homologous recombination (HR) is a ubiquitous genetic phenomenon, essential when environmental and internal stressors cause DNA damage, which can lead to breakages in both strands of double-stranded ...

Two competing models exist for homologous recombination. The results of this study support a model where the double-stranded DNA is not unwound during the homology search. (Shibata et al. Nucleic ...

Find all the latest on homologous recombination at Medical Xpress. Your go-to source for news, research, and medical breakthroughs.

Next-generation PARP inhibitor demonstrates clinical benefit in patients with homologous recombination repair-deficient breast cancer Drug has higher selectivity for PARP1, improving safety and ...

Deep Learning Artificial Intelligence Predicts Homologous Recombination Deficiency and Platinum Response From Histologic Slides – An ASCO Reading Room selection September 18, 2024 • 2 min read ...