Background: Fentanyl, a short-acting synthetic opioid, has a pharmacokinetic profile suited to fast relief of brief episodic pain. Objective: To characterize the pharmacokinetic-pharmacodynamic ...

BMC Clin Pharmacol. 2012;12(4):1-10. This study has demonstrated that the absorption mechanism is not saturable up to 1500 mg. Our results are consistent with a combination of passive and active ...