Many diseases are characterized by shifts in cellular energy metabolism. Gohil et al. use a quantitative, nutrient-sensitized screen to identify drugs that affect the relative rates of glycolysis ...

Glycolysis is a series of reactions that helpextract energy from glucose. This is an ancient pathway of metabolism that is present in the majority of living organisms today. It is the foundation ...

Glycolysis is a term used to describe the metabolic pathway involving the degradation of glucose into pyruvate and energy used to form adenosine triphosphate (ATP) and reduced nicotinamide adenine ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

To search for compounds that shift cells from respiration to glycolysis, Dr. Mootha’s team devised a new screening strategy. They cultured skin cells in two different nutrient environments ...

Oxygen-consuming organisms obtain energy through cellular respiration, which is the transformation of carbohydrates and oxygen into carbon dioxide and water. This process also produces toxic oxygen ...

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

Knockdown of PLCE1 instigates a notable attenuation of glycolysis, achieved through the modulation of ENO1 expression, a key enzyme in glycolysis. This effect was also observed in vivo . We have ...

Save guides, add subjects and pick up where you left off with your BBC account. Respiration is a chemical reaction that happens in all living cells, including plant cells and animal cells. It is ...