Glycolysis is a series of reactions that helpextract energy from glucose. This is an ancient pathway of metabolism that is present in the majority of living organisms today. It is the foundation ...

Many diseases are characterized by shifts in cellular energy metabolism. Gohil et al. use a quantitative, nutrient-sensitized screen to identify drugs that affect the relative rates of glycolysis ...

Glycolysis is an anaerobic reaction which occurs in the cytoplasm of the cell. The rest of the reactions in cellular respiration are aerobic, therefore requiring oxygen, and occur in the ...

To search for compounds that shift cells from respiration to glycolysis, Dr. Mootha’s team devised a new screening strategy. They cultured skin cells in two different nutrient environments ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

The cell NAD+/NADH ratio can constrain biomass synthesis and influence proliferation in nutrient-limited environments. However, which cell processes regulate the NAD+/NADH ratio is not known. Here, we ...

Breathing is primarily driven by the diaphragm and intercostal muscles, while respiration is driven by the cellular processes of glycolysis, the Krebs cycle, and oxidative phosphorylation.

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

Background: Our prior investigations have demonstrated that PLCE1 actively promotes tumorigenesis, angiogenesis, and cell cycle progression in ESCC. However, the precise role of PLCE1 in glycolysis ...