The central dogma of molecular biology ... mediate the addition of methyl groups or the isomerization of uradine in immature rRNA molecules, respectively. Gene regulation in both prokaryotes ...

In early embryogenesis, DNA is largely devoid of methylation (top left). Post implantation, de novo methylation begins (red circles), mediated primarily by DNA (cytosine-5-)-methyltransferase ...

The discovery of uracil and its pairing with adenine in RNA was a crucial milestone in understanding the genetic code and the central dogma of molecular biology ... Thymine has an additional methyl ...