siRNAs can be expressed from DNA constructs and silencing cell lines can be made. Among the 3 billion base pairs of the human genome, there are ∼30,000–40,000 protein-coding genes, but the ...

Researchers developed an epigenetic editing approach to silence the PCSK9 gene, achieving long-term cholesterol reduction ...

在农业生物技术领域，RNA干扰（RNAi）技术虽能精准调控基因表达，但长期受限于物种依赖性和局部作用的难题。植物具有木质部和筛管等长距离运输系统，这些系统在物质传输和信号调控中发挥核心作用，同时承载大量游离RNA，参与植物发育的多种生物学过程。即使是 ...

This promiscuous binding activity means that miRNA can act on many different mRNAs, potentially silencing hundreds of genes simultaneously. In contrast, when RNAi is guided by siRNA, the entire ...

About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time. When X-linked genes evade silencing on the “inactive” ...

The effects of targeted epigenetic silencing—in which gene function is changed without direct changes to the DNA sequence—are shown to last for nearly one year in mice and to lead to ...

Now, researchers from SLU and the James Hutton Institute have for the first time investigated how spray-induced gene silencing affects other microorganisms. RNA used to combat Fusarium head blight ...

They observed that introducing double-stranded RNA (dsRNA) into the worm led to the silencing of genes with complementary sequences. This discovery laid the foundation for understanding the mechanism ...

Queensland University researchers have ventured into a new approach called ‘gene silencing’ for the treatment of cervical cancer. The technique is targeted towards turning the cancer causing ...

Registration Link for Presentation and live Q&A to take place, Tuesday February 4, 2025 at 2:00 pm ESTMarlborough, Massachusetts--(Newsfile ...