Mutations that disrupt the trpR gene lead to elevated production ... into several general principles involved in regulation in eukaryotes. For example, specific sequences in DNA serve as binding ...

For example, the study identified HNF4 and GATA ... help to better equip researchers to unravel the complexities of gene regulation and to explore the vast, uncharted territories of the human ...

This offers insights into cell-specific gene regulation and potential links to ... the identification of distal regulatory elements. For example, GET achieved experimental-level precision in ...

Along our journey, we shall reveal basic principles of gene regulation. We aim to exploit the new knowledge to help devise novel treatments of many diseases that stem from misregulated gene ...

for example in embryonic stem cells. This combination offers incredibly precise regulation of gene activity, essential to the development of organisms and the harmonious functioning of cells.

When transcriptional regulation fails to perform properly, unsuitable patterns of gene expression happen which can result in disease. For example, a different study by Princeton University ...