SNPs in the PAM region leading to guanine (G) to Y change, where Y represents cysteine (C) or taurine (T), were preferred, as these changes exhibited the best discrimination of scFv-DNMT3A/3L ...

Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease.