Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression. This straightforward experiment demonstrated that it was ...

Epigenetic variation, like genetic variation, can be inherited and influence traits across generations. However, epigenetic ...

In early embryogenesis, DNA is largely devoid of methylation (top left). Post implantation, de novo methylation begins (red circles), mediated primarily by DNA (cytosine-5-)-methyltransferase ...

These findings could reshape our understanding of gene expression and disease. Key findings include: Scope of bimodal methylation: Identification of 325,000 genomic regions—approximately 6% of ...

“These findings open new avenues for investigating how parental methylation influences gene regulation and the development of certain diseases.” Using machine learning algorithms and deep ...

DNA methylation affects many biological processes, including gene expression, embryonic development, inflammation, and cellular proliferation and differentiation. Several complex diseases have ...

A new study highlights the placenta’s role in neuropsychiatric development, showing that DNA methylation influences gene ...

“Today, when we don’t know what causes a disease, we say it’s likely epigenetic. In a sense, I think this epigenetic viewpoint is right, but we need much more evidence to get a defined picture.” Cedar ...

An international team, led by the Immunogenetics Research Laboratory (IRLab) at the University of the Basque Country (UPV/EHU) and the Biobizkaia Health Research Institute, has identified associations ...

For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...

Epigenetics is the study of heritable changes in gene expression that do not involve alterations to the DNA sequence. Epigenetic modifications, such as DNA methylation and histone modifications, can ...

These findings could reshape our understanding of gene expression and disease. This research leverages the power of whole-genome bisulfite sequencing to characterize DNA methylation patterns at an ...