The research field of 'cellular IRESes' lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated ...

This process of protein synthesis occurs in two stages - transcription and translation. When a gene is to be expressed, the base sequence of DNA is copied or transcribed into mRNA (messenger RNA).

TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...

The research field of "cellular IRESes" lay dormant for decades, as there was no uniform standard of reliable methods for the ...

So how does protein synthesis make hair? If you've looked at the activity (or even the text version of the activity), you know how a section of DNA instructs a cell how to make a protein.

Only recently has the ribosome - one of the oldest molecular machines in evolutionary terms - been recognized as an active regulator of gene expression at the level of protein biosynthesis.

These modifications can regulate gene expression and increase mRNA stability. Ribosomes, the cellular machines responsible for protein synthesis, are essential for all living organisms.

Mutations could cause different genes to be switched on or off, and this could create a different or faulty protein to be synthesised. For example, if the protein is an important enzyme ...

The research combined cell-free DNA assembly, gene expression, and functional assays ... researchers used cell-free protein synthesis (CFPS) to generate sequence-function data, eliminating ...