Much of the difficulty of determining the contributions of individual residues to protein structure and function stems from the need to generate and evaluate a large number of mutants. The ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function.

Functional protein design, particularly for proteins ... complex molecular–protein interactions and capturing sequence-structure dependencies. PocketGen addresses these issues, offering a ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process ... to ...

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions ...

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

The specific structure of a protein determines its unique biological function. (click on image to enlarge) (Image: National Human Genom Research Institute) Proteins are built from a set of 20 standard ...

functional, and molecular information. Although the rational protein design approach offers an increased possibility of beneficial alterations, it is not easy to accurately predict the ...

Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function. Researchers have long known that the ...