Researchers from Soochow University and affiliated organizations presented data from a study that aimed to investigate the role of cyclic GMP-AMP synthase (cGAS) in tumorigenesis and tumor progression ...

Upon light irradiation, it can induce lysosomal dysfunction by generating a large amount of reactive oxygen species and heat, leading to the pyroptosis and ferroptosis of tumor cells. This process ...

Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This ...

both primary and distant tumor growth in mice was significantly inhibited. This research introduces a novel strategy for designing dual-function pyroptosis and ferroptosis inducers, paving the way ...

Ferroptosis, a form of iron-dependent cell ... USP48 and gasdermin E (GSDME), which contribute to immune responses and tumor suppression. Beyond their influence on PCD, USPs play a role in tumor ...

Upon light irradiation, it can induce lysosomal dysfunction by generating a large amount of reactive oxygen species and heat, leading to the pyroptosis and ferroptosis of tumor cells. This process ...

After targeting lysosomes, M@P can cause lysosome dysfunction through the generation of reactive oxygen species and heat under light irradiation, triggering pyroptosis and ferroptosis of tumor cells, ...

Certain TCM compounds and monomers exhibit remarkable efficacy in enhancing or inhibiting ferroptosis, thereby offering a dual strategy to either suppress tumor growth or protect healthy tissues ...

Tumor metastasis, recurrence, and therapeutic resistance are the main reasons for the failure of clinical cancer treatment. Studies have found that the presence of cancer stem-like cells (CSCs ...