为解决哮喘发病机制和治疗反应相关遗传变异研究的难题，研究人员开展了 “Enhancer RNA 转录精准定位与哮喘相关的功能性遗传变异” 研究。通过对大样本队列分析，发现 35 个与哮喘相关的单核苷酸多态性（SNPs），明确了空气污染、糖皮质激素信号与哮喘的新关联，为哮喘研究提供新方向。

Oncogene - A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response Skip to main content Thank you for visiting nature.com.

image: This shows the sense of antisense RNA. view more Credit: SISSA. To synthetize proteins, the DNA needs RNA molecules serving as short "transcriptions" of the genetic information.

"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat." Nature, 2012, DOI: 10.1038/nature11508. About RIKEN.

Non-coding antisense RNA can be used to stimulate protein production Date: October 16, 2012 Source: RIKEN Summary: While studying Parkinson's disease, an international research group made a ...

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Enhancer RNA profiling predicts transcription factor activity. Published:2/15/2018 2/15/2018 . Genome Res. 2018 Feb 15. doi: 10.1101/gr.225755.117. ... Active enhancers are often characterized by the ...

Antisense instead binds to the RNA messenger molecules that ferry genetic information from the DNA to the cell. By binding to RNA, antisense prevents proteins involved in disease from ever being ...

For at least 30 years scientists and drug developers bent on a sorely needed new class of therapeutics have been studying antisense RNA. The concept is deceptively simple: Binding of an ...

Bidirectional transcription from the promoter region and enhancers produces non-coding promoter RNA (pRNA) and enhancer RNA (eRNA), respectively. Natural antisense transcripts (NATs) originating from ...