image: This shows the sense of antisense RNA. view more Credit: SISSA. To synthetize proteins, the DNA needs RNA molecules serving as short "transcriptions" of the genetic information.

"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat." Nature, 2012, DOI: 10.1038/nature11508. About RIKEN.

Non-coding antisense RNA can be used to stimulate protein production Date: October 16, 2012 Source: RIKEN Summary: While studying Parkinson's disease, an international research group made a ...

A study investigating the function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy. According to the study researchers, altering the production and function ...

Bidirectional transcription from the promoter region and enhancers produces non-coding promoter RNA (pRNA) and enhancer RNA (eRNA), respectively. Natural antisense transcripts (NATs) originating from ...

For at least 30 years scientists and drug developers bent on a sorely needed new class of therapeutics have been studying antisense RNA. The concept is deceptively simple: Binding of an ...

The studies, each of which uses different methodologies, find RNA polymerase II boarding both upstream and downstream of start sites, and generating antisense RNA at many places across the genome.

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Much of the non-coding RNA is produced as the complementary strand to mRNA and is therefore referred to as antisense RNA (asRNA). Their function has been unclear for a long time.

When LINE-1 RNA was depleted in human progeroid cells using antisense oligonucleotides the senescent phenotypes were ameliorated, while in the premature aging mouse model this therapy restored tissue ...