Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Specifically, in eukaryotes, transcription is achieved by three different types of RNA polymerase (RNA pol ... Together with other common motifs (short recognition sequences in the DNA), these ...

Researchers have identified an ancient RNA-guided system that can target DNA, potentially expanding the genome-editing toolbox.

Zhang's team discovered over 20,000 different Tas proteins, mostly occurring in bacteria-infecting viruses. Sequences within each gene's repetitive region—its TIGR arrays—encode an RNA guide ...