plays a central role in DNA repair by cleaving the DNA backbone 5′ of AP sites that result from removal of damaged bases. New structural findings on APE1–DNA cocrystals provide insights into ...

Structural Basis for Nick Recognition by a Minimal “Pluripotent” DNA ligase Although ChVLig lacks the large N- or C-terminal flanking domains found in eukaryotic cellular DNA ligases, it can sustain ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs ... Pavletich NP. 2002. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure ...

LIG4 syndrome is an exceptionally rare disorder caused by a genetic mutation that prevents the body from repairing damaged ...

DNA is a complex molecule that consists of two strands coiled around each other to form a double helix structure. Comparison of a single-stranded RNA and a double ... To maintain the integrity of the ...

But James Watson and Francis Crick's claim was a valid one, for they had in fact discovered the structure of DNA, the chemical that encodes instructions for building and replicating almost all ...

New research about how smoking damages DNA could open new possibilities for targeted cancer prevention.Israeli and US ...

Earlier that morning, in the nearby Cavendish laboratory, the two scientists had discovered the structure of deoxyribonucleic acid, or DNA. This discovery changed the world of science and medicine ...

The study from The Hebrew University of Jerusalem, led by Prof. Sheera Adar and her graduate student Elisheva Heilbrun-Katz ...

The research suggests that the body's ability to fix DNA damage is more important than the extent of the damage itself in ...

The study, published in Nucleic Acids Research, focused on benzo (a)pyrene, a toxic chemical in cigarette smoke, which binds to DNA when processed by the body, and disrupts its normal function and ...