Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen.

Earlier studies had suggested that these drugs, known as DNA methyltransferase inhibitors (DNMTis), worked by triggering the expression of ... methyl groups that attach to and block transcription of ...

Switzer, R. L., Hartman, Z. J.*, Hewett, G. R.*, and Carroll, C. F.* (2023) “Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1” DNA 3, 119 ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

A clinical trial found that omega-3 supplementation modestly slowed biological aging, with additional benefits when combined with vitamin D and exercise.

Several clinical trials are testing to inhibit the LSD1 protein's ability ... a support structure for other proteins that ...

Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to ...