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Collagen, the body's most abundant protein, has long been viewed as a predictable structural component of tissues. However, a ...
4 天
AZoLifeSciences on MSNCryo-EM Uncovers Hidden Complexity in Collagen StructureThe most prevalent protein in the body, collagen, has long been thought to be a predictable structural element of tissues.
"For decades, we have assumed that collagen triple helices always follow a strict structural paradigm. Our findings show that collagen assemblies can adopt a wider range of conformations than ...
Figure 1: Pauling and Corey's first guess at the structure of collagen, showing a beautifully drawn illustration of their proposed three-chain helix: it was wrong, and they later withdrew it.
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