The diminutive chromosome 21--the smallest of the human contingent, despite its number as next to last--is the fourth to be described. Its debut in mid-May attracted attention because 21 is a ...

The presence of three copies of chromosome 21, which harbors the amyloid precursor protein (APP) gene, is the most common genetic cause of Alzheimer’s disease. Carriers of this alteration have Down ...

Decades of tests had shown that she had both Down syndrome and an intermediate level of Alzheimer's. Physical examinations ...

Every year, about 7.9 million infants (6% of worldwide births) are born with serious birth defects. With the causes of over 50% of birth defects unknown, how do we diagnose and prevent them?

"You either have XX or XY chromosomes," Rep. Nancy Mace, R-S.C., wrote Feb. 20 on X. "Those are the options." Most commonly, a person is born with two X chromosomes (female) or an X and a Y (male).

(Reuters) - Gene editing techniques may one day allow for the removal of the extra chromosome that causes Down syndrome, early experiments suggest. Down syndrome, or trisomy 21, is caused by the ...

World Down Syndrome Day is right around the corner, and I invite you to join us in celebrating on March 21! This special day ...

More information: Ryotaro Hashizume et al, Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells, PNAS Nexus (2025). DOI: 10.1093/pnasnexus/pgaf022 ...

What is the structure of a chromosome? Why does the total number of chromosomes in a cell matter? Learn how chromosomes self-organize within single cells, and how these patterns help us detect ...