These data suggest that protein misfolding is responsible for the nuclear aggregates seen in SCA1, and that overexpression of a DnaJ chaperone promotes the recognition of a misfolded polyglutamine ...

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another.

Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, ...

The balance of protein folding and degradation is one of the most fundamental activities of the cell, and is a critical point of intervention in cancer, metabolic, and aging diseases. Molecular ...

In addition, we investigate the quality control, physiological regulation, and disease connections of trafficking complex assembly. 1. Chaperone-assisted Adaptor Protein Assembly (CAPA). Our group ...

and lifespan The activity and quality of mitochondrial proteins must be controlled to match the dynamic needs of eukaryotic organisms. This control is accomplished both by a chaperone machinery ...

The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and ...

Langer, R. Boteva, A. Schramel, A.L. Horwich, F.-U. Hartl, "Chaperonin-mediated protein folding at the surface of groEL through a `molten globule'-like intermediate," Nature, 352:36-42, 1991.

HSP90 chaperone undergoes dynamic cycling process: HSP90 transits between open and closed states to promote maturation of polypeptide clients into functional proteins with the help of ATP and a ...

they combed the proteome for mechanisms that could cause less protein aggregation or clear up existing protein clumps. That’s how they came across cyclophilin A, a chaperone that was highly expressed ...

We determined the structure and function of Heat Shock Protein 90 (Hsp90), a molecular chaperone which is critical for the growth and survival of cancer cells. We worked with partners to discover the ...