CRISPR–Cas9 has limitations. One of the most concerning, in regards to using genome editing for therapeutic applications for humans, is off-target DNA cleavage. Although some Cas9 variants have ...

A compact RNA-guided enzyme, NovaIscB, derived from bacterial IscBs—evolutionary ancestors of Cas9—has been engineered for efficient, programmable genome editing in human cells.

Discover how CRISPR-Cas9 technology is revolutionizing spider silk production with red fluorescent fibers and advancing genetic research.

Conference expulsion? No penalty structure? Questions mount as college sports enforcement comes into focus As the House v. NCAA decision draws near, questions remain over what the college sports ...

The research article, “ Cryo-shocked tumor cells deliver CRISPR-Cas9 for lung cancer regression by synthetic lethality, ” was published in Science Advances. Cell-based gene editing delivery ...

Capital structure refers to the mix of funding sources a company uses to finance its assets and its operations. The sources typically can be bucketed into equity and debt. Using internally ...

The University of Bayreuth's Biomaterials research group has, for the first time, successfully applied the CRISPR-Cas9 gene-editing tool to spiders. Following the genetic modification, the spiders ...

The predicted orientation of the Cas9 protein on the AFM substrate is shown, and a simulated AFM image calculated in the scanning view perspective shows remarkable agreement with previous HS-AFM ...

An exon-skipping technique using dual single-guide RNA/Cas9 ribonucleoproteins targeted at 3 novel COL7A1 exons with pathogenic heterozygous mutations achieved exon deletion rates of up to 95%.

The authors of this article review recent applications of CRISPR-Cas9-based gene editing technology in mosquito-borne disease prevention and control, as well as mosquito population suppression ...

CRISPR is a versatile tool for editing genomes and has recently been approved as a gene therapy treatment for certain blood disorders. When you purchase through links on our site, we may earn an ...