编辑丨王多鱼排版丨水成文抗 PD-1 联合仑伐替尼（lenvatinib，一种多靶点受体酪氨酸激酶抑制剂）治疗在多种肿瘤中均显示出临床疗效，但潜在的免疫学机制尚不清楚。2025 年 1 月 30 ...

肿瘤免疫治疗是癌症治疗领域的重要方向，然而肿瘤免疫逃逸严重阻碍了治疗效果的提升。CD8+ T ...

Here we have designed a CAR, CD4CAR, which redirects the antigen specificity of CD8+ cytotoxic T cells to CD4-expressing cells. CD4CAR T cells derived from human peripheral blood mononuclear cells ...

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

We also determined which CD4 + T cell population is critical for induction of negative regulation of CTL tumor immunosurveillance, and found it was dependent on CD1-restricted NKT cells.

在Nature Cancer期刊以长文的形式发表了题为“ETV7 limits the antiviral and anti-tumor efficacy of CD8+ T cells by diverting their fate towards exhaustion （ETV7通过促进CD8+ T细胞命运向耗竭的转化，限制CD8+ T细胞抗病毒和抗肿瘤的功能）的研究论文 CD8 + ...

Peripheral blood CD4 + /CD8 + ratios at 12 and 24 weeks may serve as predictive markers for HBsAg clearance in IHCs treated with peg-IFN-α. view more Credit: Shuangsuo Dang, Fengping Wu ...

Typically, in advancing disease, as the immune system becomes exhausted, it is less able to produce T-cells to defend itself. The CD4/CD8 percentage helps healthcare practitioners see this.

The stem-like CD4 T cells have the ability to renew themselves and transform into different immune cell types. These cells ...

Comparatively, GZMB-expressing KIR+ CD8+ T-cells have been found to suppress autoimmunity by eliminating autoreactive CD4+ T-cells. The current study is the first to report the persistence and re ...