1996b) , the vector pCMVΔR8.2 supplies all but the HIV envelope in ... These features, in conjunction with several other biosafety enhancements, prevent recombination of replication-competent HIV. All ...

The technology for this strategy has already been developed for Aedes aegypti 3 —the main vector of dengue fever—and its biosafety implications are relatively manageable because transgenes are ...

This project builds on recent work reporting tick transmission of relapsing fever spirochetes and genome sequencing of both the pathogen and tick vector. We have utilized both next generation and ...