Neurodegenerative diseases pose a serious threat to public health, with an increasing impact among the elderly population.

While this mechanism has so far only been shown in mice, further studies will investigate how autophagy regulates metabolism in both mouse and human-based models of neurodegenerative diseases.

The pharmacological stimulation of autophagy may have cytoprotective effects, for example, in mouse models of neurodegenerative disease, whereas the inhibition of autophagy can sensitize cancer ...

Josephine Thinwa shares her journey to becoming a physician scientist and how this led her to investigate the role of a neurologically important kinase in virus-induced autophagy ... to accelerate ...

More information: Suhyun Kim et al, Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in ...

Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning ...

Every year, neurodegenerative diseases take a steep toll on millions of people, affecting individuals, their caregivers, families and communities. Most neurodegenerative diseases share a common ...

Oct. 2, 2023 — A chloroplast enzyme safeguards plants against pathological protein aggregation that causes Huntington’s and other neurodegenerative diseases. New research may have found a way ...

Our cells constantly receive DNA damage from factors such as ultraviolet rays, irradiations, toxins and chemicals. For women, ...

Impaired autophagy precedes both amyloid beta and tau tangles, and therefore anticipates the neurodegenerative process in Alzheimer’s disease. 1 Hence, stabilization or restoration of autophagy ...

Impairment of autophagy precedes both amyloid beta and tau tangles, and therefore anticipates the neurodegenerative process in Alzheimer’s disease NEW YORK, Jan. 15, 2025 (GLOBE NEWSWIRE ...

In recent years, autophagy has also been recognized ... microglia are advancing neuroinflammation research and neurodegenerative disease modeling.